Laboratory of physicochemical investigations

The laboratory was established in 2002. The Head of the laboratory is L. Ivashkevich, Ph. D., Associate professor.


  Directions of the research activity:

  •  x-Ray diffraction investigations of molecular and crystal structures of organic and inorganic compounds using both single crystals and powders;
  •  investigation of physicochemical processes of spontaneous and directed nanostructuring of silicon single crystal surfaces.




Main achievements:

  • crystal and molecular structure of more than 100 tetrazole derivatives has been determined, which represent complexes of tetrazoles with transition metals, substituted tetrazoles and tetrazolium salts:

- complete characteristic of crystal structure of the compounds (metric data, bond lengths, valency and torsion angles, coordination polyhedras,
packing of the molecules in the crystal, the system of hydrogen bonds and others) has been obtained,
- new ways of coordination of ligands have been identified and their relation to with the nature of the ligands has been established,
- ability of 1,5 - dialkiltetrazols to bridging coordination through the tetrazole cycle has been discovered,
- effect of differences in coordination properties inherent to 1H- and 2H- isomers of substituted tetrazols on the structure of coodinating compounds have been studied,
- influence of the nature of the tetrazole cycle substituents on the character of the crystal complex architecture has been investigated,
- spin state of iron(II) and cobalt(II) in complexes has been investigated on the basis of X-ray data,
- methodology of structural investigations of complexes by a powder diffraction method which permitted to establish the structure of a significant number of poorly-crystallizing compounds has been developed;

  • crystal and molecular structure of 50 biologically active compounds (steroids, homogonanes etc.) has been established;
  • a set of experimental and technological equipment to investigate regularities of nanomorphology transformation of solid surfaces in various physicochemical conditions has been created.


   
 

Developments:
  •   method of complete X-ray analysis of crystalline substances implemented into the practice of scientific research;
  •   a set of programs «Diamond» assighned for the computer simulation of the process of diamond type single crystals dissolution.


Main publications of the last years:

 

  1. Voitekhovich S.V., Lyakhov A.S., Degtyarik M.D., Grigoriev Y.V, Shiman D.I., Klose J., Stepurko E.N., Blokhin A.V., Ivashkevich L.S., Kersting B., Ivashkevich O.A. Dicopper (II) complexes with N3, N4-bridging 1-alkyltetrazoles: Synthesis, crystal structure, magnetic and thermodynamic properties// Journal of Solid State Chemistry (2023). 321. P. 123876 https://doi.org/10.1016/j.jssc.2023.123876 (IF – 3.3)
  2. Siamionau A.V., Ragoyja E.G., Egorov V.V. A feasible, fast and reliable method for estimating ion-site association constants in plasticized PVC ion-selective electrode membranes // Analytica Chimica Acta (2023). 1239. P. 340556 https://doi.org/10.1016/j.aca.2022.340556 (IF – 6.2)
  3. Egorov V.V., Siamionau A.V., Ragoyja E.G. H+-Selective Electrodes Based on Amine-Type Ionophores: Generalized Theory and A Priori Quantification of Lower and Upper Detection Limits // ACS Sensors. (2023). 8 (5). pp. 2087–2095 https://doi.org/10.1021/acssensors.3c00417 (IF – 8.9)
  4. Salih F.A., Novakovskii A.D., Egorov V.V. Insight into response of ion-exchanger-based electrodes sensitive to highly lipophilic physiologically active amines // Journal of Electroanalytical Chemistry (2022). 920. № 116561. DOI: 10.1016/j.jelechem.2022.116561(IF – 4.598)
  5. Siamionau A.V., Egorov V.V. Determination of Single-Ion Partition Coefficients between Water and Plasticized PVC Membrane Using Equilibrium-Based Techniques // Membranes (2022). 12 (10). № 1019. DOI: 10.3390/membranes12101019 (IF – 4.562)
  6. Salih F.A., Novakovskii A.D., Egorov V.V. Verapamil-Sensitive Electrodes: Main Factors Responsible for Analytical Performance and Use in Drug Analysis // Journal of Analytical Chemistry (2022). 77 (12). pp. 1586-1594. https://doi.org/10.1134/S1061934822120127 (IF – 1.069)
  7. Grigoryev E.Y., Grigorieva I.M., Lyakhov A.S., Ivashkevich L.S., Matulis V.E., Lavrenova L.G., Voitekhovich S.V., Grigoriev Y.V. 2,6-Di(1H-tetrazol-1-yl)pyridine and its cupric chloride complex //  Zeitschrift fur Anorganische und Allgemeine Chemie (2022). 648 (22). № e202200290. DOI: 10.1002/zaac.202200290 (IF – 1,414).
  8. Voitekhovich S.V., Lyakhov A.S., Ivashkevich L.S., Matulis V.E., Grigoriev Y.V., Klose J., Kersting B., Ivashkevich O.A. 5-Amino-2-isopropenyltetrazole and its Cupric Chloride Complex: Synthesis, Structure and Magnetism // Zeitschrift fur Anorganische und Allgemeine Chemie (2022). 648 (22). № e202200213. (IF 1,414) DOI: 10.1002/zaac.202200213 (IF – 1.414)
  9. Budevich V.A., Voitekhovich S.V., Zuraev A.V., Matulis Vadim E., Matulis Vitaly E., Lyakhov A.S., Ivashkevich L.S., Ivashkevich O.A. Mesoionic tetrazolium-5-aminides: synthesis, molecular and crystal structures, UV-Vis spectra, and DFT calculations // Beilstein J. Org. Chem. (2021). 17. P. 385-395. (IF ‒ 2.883)
  10. Serebryanskaya T.V., Lyakhov A.S., Ivashkevich L.S., Grigoriev Y.V., Kritchenkov A.S., Khrustalev V.N., Tskhovrebov A.G., Ivashkevich O.A. Novel tetrazole PtII and PdII complexes with enhanced water solubility: synthesis, structural characterization and evaluation of antiproliferative activity // Zeitschrift für Kristallographie – Crystalline Materials. (2021). 236. pp. 23-32. (IF ‒ 1.179)
  11. Voitekhovich S.V., Grigoriev Y.V., Lyakhov A.S., Ivashkevich L.S., Klose J., Kersting B., Ivashkevich O.A. Polymeric chain complexes of copper(II) chloride with 1,5-disubstituted tetrazoles: structure and magnetic properties // Polyhedron. (2021). 194. P. 114907. (IF ‒ 3,052)
  12. Voitekhovich S.V., Lyakhov A.S., Ivashkevich L.S., Lavrov A.N., Lavrenova L.G., Ivashkevich O.A. Direct synthesis and characterization of copper(II) 1-phenyltetrazol-5-olates // Z. Anorg. Allg. Chem. (2021). 647. P.1633-1638. (IF ‒ 1.492)
  13. Voitekhovich S.V., Lyakhov A.S., Ivashkevich L.S., Ivashkevich O.A. Copper-assisted desulfurization of 1-R-tetrazole-5-thiols under complexation // Inorganic Chemistry Communications. 2020. Vol. 114. 107827 (IF 1.943)
  14. Kletskov A.V., Bumagin N.A., Petkevich S.K., Ivashkevich L.S., Kolesnik I.A., Potkin V.I. Mimics of Pincer Ligands: An Accessible Phosphine-Free N-(Pyrimidin-2-yl)-1,2-azole-3-carboxamide Framework for Binuclear Pd(II) Complexes and High-Turnover Catalysis in Water // Inorganic Chemistry. 2020. Vol. 59(15). P. 10384-10388(IF  4.825).
  15. Voitekhovich S.V., Degtyarik M.M., Lyakhov A.S., Ivashkevich L.S., Kersting B., Ivashkevich O.A. Halido-bridged Copper(II) Complexes with 1-tert-Butyl-1H-tetrazole: Crystal Structure and Magnetic Properties // Zeitschrift fur Anorganische und Allgemeine Chemie. 2020. Vol. 646(15). P. 1331-1335
  16. Voitekhovich S.V., Lyakhov A.S., Shiman D.I., Ivashkevich L.S., Kersting, B., Ivashkevich, O.A. 1,3-Bis(1-methyl-1H-tetrazol-5-yl)propane and its coordination polymers with Cu2Cl4 and Cu3Cl6 units // Polyhedron. 2020. Vol. 190. 114793(IF 2.067 )
  17. Egorov V.V.,  Novakovskii A.D., Salih F.A.,  SemenovA.V., Akayeu Y.B. Description of the effects of non‐ion‐exchange extraction and intra‐membrane interactions on the ion‐selective electrodes response within the interface equilibria‐triggered model // Electroanalysis. 2020.  Vol. 32. № 4.  P. 674–682. (IF 2,54).
  18. Charapitsa S., Sytova S., Kavalenka A.,Sobolenko L.,Kostyuk N., Egorov V., Leschev S., Vetokhin S., Zayats, N. The study of the matrix effect on the method of direct determination of volatile compounds in a wide range of alcoholic beverages // Food Control. 2020. 107528. DOI: 10.1016/j.foodcont. (IF 4,258).
  19. Korban A.,  Charapitsa S.,  Čabala R., Sobolenko L., Egorov V.,  Sytova S. Advanced GC-MS method for quality and safety control of alcoholic products// Food Chemistry. 2020. 128107. DOI: 10.1016/j.foodchem. (IF 6,306).
  20. Egorov, V. V. Novakovskii A.D. On the possibilities of potentiometric analysis in presence of small concentrations of highly interfering foreign ions: Ways for reducing the interference  // J. Electroanal. Chem.  2019. Vol. 847. № 113234.  P. 1–6.
  21. Egorov, V. V. , Novakovskii A.D. Overcoming of one more pitfall in boundary element calculations with computer simulations of ion-selective electrode response  // ACS Omega.  2019.  Vol. 4.  P. 1617–1622.     (IF 2,584)
  22. Egorov, V. V., Novakovskii A.D.  On the possibilities of potentiometric analysis in presence of small concentrations of highly interfering foreign ions: Ways for reducing the interferencei // J. Electroanal. Chem.  2019.  Vol. 4.  P. 1617–1622. (IF 3,218)
  23. Charapitsa S., Sobolenko L., Sytova S., Korban A., Egorov V., Leschev S., Zakharov M., Cabala R., Busarova R., Shestakovich I., Tolstouhova A., Ondrousek S., Vavra J., Yilmaztekin M., Cabaroglu T.  Interlaboratory Study of Ethanol Usage as an Internal Standard in Direct Determination of Volatile Compounds in Alcoholic Products  // BIO Web of Conferences 42nd World Congress of Vine and Wine.  2019.  Vol. 15. №02030.  8 pp. https://doi.org/10.1051/bioconf/20191502030.
  24. Voitekhovich S.V., Lyakhov A.S., Matulis Vad.E., Ivashkevich L.S., Ivashkevich O.A.. Substituent-Dependent Coordination Modes of 1-Methyl-5-R-tetrazoles in Their Cupric Chloride Complexes // Polyhedron. 2019. Vol. 162.  P. 100–110. 
  25. Voitekhovich S.V., Grigoriev Yu.V., Lyakhov A.S., Matulis Vad. E., Ivashkevich L.S.,  Ivashkevich O.A..  2-(1H-tetrazol-1-yl)thiazole: Complexation and copper-assisted tetrazole ring transformation // Polyhedron. 2019. Vol. 171. P. 423–432.
  26. Voitekhovich S.V.,Grigoriev Yu.V., Lyakhov A.S., Matulis Vad. E.,  Ivashkevich L.S., Bogomyakov A.S., Lavrenova L.G., Ivashkevich O.A..1-(1,2,4-Triazol-3-yl)-1H-tetrazoles and their complexation with copper(II) chloride // Polyhedron. 2019. https://doi.org/10.1016/j.poly.2019.114299 .
  27. Voitekhovich S.V., Degtyarik M.M., Lyakhov A.S., Ivashkevich L.S., Ivashkevich O.A. Copper(II) Halide Complexeswith 1-tert-Butyl-1H-1,2,4-triazole and 1-tert-Butyl-1H-tetrazole// Zeitschrift für Anorganische und Allgemeine Chemie.  2018.  Vol. 644. P. 100–108.
  28. Grigorieva I.M., Serebryanskaya T.V., Grigoriev Y.V., Lyakhov A.S., Ivashkevich L.S., Bogomyakov A.S., Lavrenova L.G., Voitekhovich S.V., Ivashkevich O.A.Transition metal chelatecomplexes with tetrazole derived Mannich base: metal dependent architecture and properties // Polyhedron. 2018. Vol. 151.  P. 74–81.
  29. Voitekhovich S.V., Mosalkova A.P., Lyakhov A.S., Ivashkevich L.S., Schmorl S., Kersting B, Ivashkevich O.A.Selective Synthesis and Complexation of Novel N,N'-Alkylene-Bridged Bis(5-pyridyltetrazole) // Z. Anorg. Allg. Chem. 2018. Vol. 644. P. 1611–1617.
  30. Voitekhovich S.V., Lyakhov A.S., Ivashkevich L.S., Schmorl S., Kersting B., Ivashkevich O.A. The First Characterized Coordination Compounds of Macrocyclic Ligands Including Incorporated Tetrazole Rings// Crystal Growth & Design. 2017. Vol. 17. Р. 1796–1805.
  31. Zuraev A.V., Grigoriev Y.V., Lyakhov A.S., Ivashkevich L.S., Ivashkevich O.A. Copper-Polymer Nanocomposite Catalyst for Synthesis of 1,4-Diphenylbutadiyne-1,3// Zeitschrift für Anorganische und Allgemeine Chemie.  2017. Vol. 643.  P.1215–1219.
  32. Voitekhovich S.V., Grigoriev Y.V., Lyakhov A.S., Ivashkevich L.S., Ivashkevich O.A. The first organocopper tetrazole derivative: synthesis and characterization// Dalton Transactions. 2016. Vol. 45. Р. 13406–13414.
  33. Voitekhovich S.V., Wolf A., Guhrenz C., Lyakhov A.S., Ivashkevich L.S., Adam M., Gaponik N., Kaskel S., Eychmüller A. 5-(2-Mercaptoethyl)-1H-tetrazole: Facile Synthesis and Application for Preparation of Water Soluble Nanocrystals and Their Gels// Chemistry European J. 2016. Vol. 22. P. 14746–14752.
  34. Serebryanskaya T.V., Lyakhov A.S., Ivashkevich L.S., Schur J., Frias C., Prokop A., Ott I. Gold(I) Thiotetrazolates as Thioredoxin Reductase Inhibitors and Antiproliferative Agents// Dalton Transaction. 2015. Vol. 446.  P. 1161-1169.
  35. Andreeva T.N., Lyakhov A.S., Ivashkevich L.S., Voitekhovich S.V., Grigoriev Y.V., Ivashkevich O.A. 1-(Furan-2-ylmethyl)-1H-tetrazole and its Copper(II) Complexes // Zeitschrift für Anorganische und Allgemeine Chemie.  2015. Vol. 641.  P. 2312-2320.
  36. Degtyarik M.М., Lyakhov A.S., Ivashkevich L.S., Matulis V.E., Matulis V.E., Gruschinski S., Voitekhovich S.V., Kersting B., Ivashkevich O.A. Copper(II) tetrafluoroborate complexes with the N3,N4-bridging coordination of 1-(tert-butyl)-1H-tetrazole: synthesis, crystal structure and magnetic properties// Dalton Transactions.  2015. Vol. 44.  P. 18518-18526.