image of the person

Yaroslav Faletrov

EN | RU

Leading Researcher
PhD (Chemistry)
Docent (Associate professor)

Department: Laboratory of biochemistry of drugs
e-mail: yaroslav82@tut.by
Phone: +375 (17) 200-82-72

 

h-index (Scopus) – 7,
h-index (Web of Science) – 6,
h-index (Google scholar) – 8,
https://scholar.google.ru/citations?user=S2xopSIAAAAJ&hl=ru
 
Subject and Class of Degrees

  • 2013 – PhD in biochemistry, Institute of Bioorganic Chemistry, National Academy of Science, Belarus;
  • 1999-2004 – Chemistry Department, Belarusian State University (diploma -  pharm. chemistry);
  • 2005  Degree of Master of Natural Sciences. Chemistry Department, Belarusian State University, Minsk, Belarus.

Career

  • 2017-  now   Leading researcher in the Laboratory of Biochemistry of Drugs, RI PCP BSU;
  • 2014-2017      Senior researcher in the Laboratory of Biochemistry of Drugs, RI PCP BSU;
  • 2012-2014      Researcher in the Laboratory of Biochemistry of Drugs, RI PCP BSU;
  • 2005-2012      Junior researcher in the Laboratory of Biochemistry of Drugs, Research Institute for Physical Chemical Problems (RI PCP BSU).


Current research activity, main achievements

Docking-based virtual screening, fluorescent and steroidal compounds; design, synthesis and evaluation their physic-chemical and biological properties.
 
List of the selected publications

  1. Panada J, Klopava V, Kulahava T, Frolova N, Faletrov Y, Shkumatov V. New 3(3-hydroxysteroid-in dolamine conjugates: Design, synthesis and inhibition of C6 glioma cell proliferation // Steroids.  2020.  Vol. 164. P. 108728. doi: 10.1016/j.steroids.2020.108728. 
  2. Ya.V. Faletrov et al. // Chem Phys Lipids. –  2020 – Vol. – P.104850.
  3. K.V. Tugaeva et al. // Biochem. Biophys. Res. Commun. – 2018. – 497. – P. 58-64.
  4. Faletrov Y.V., Efimova V.S., Horetski M.S., Tugaeva K.V., Frolova N.S., Lin Q., Isaeva L.V., Rubtsov M.A., Sluchanko N.N., Novikova L.A., Shkumatov V.M. New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells // Chem. Phys. Lipids. 2020. Vol. 227. P. 104850. doi: 10.1016/j.chemphyslip.2019.104850.
  5. Tugaeva K.V., Faletrov Y.V., Allakhverdiev E.S., Shkumatov V.M., Maksimov E.G., Sluchanko N.N. Effect of the NBD-group position on interaction of fluorescently-labeled cholesterol analogues with human steroidogenic acute regulatory protein STARD1 // Biochem. Biophys. Res. Commun.  2018.  Vol. 497. P. 58-64.
  6. Faletrov Y., Brzostek A., Plocinska R., Dziadek J., Rudaya E., Edimecheva I., Shkumatov V. Uptake and metabolism of fluorescent steroids by mycobacterial cells // Steroids.  2017. Vol.117. P.29-37.
  7. N.V. Loginova et al. // Polyhedron. – 2015. – Vol. 88. – P. 125–137.
  8. Loginova N.V., Koval’chuk T.V., Osipovich N.P., Faletrov Y.V., Halauko Yu.S.,. Polozov G.I, Gres’ A.T., Harbatsevich H.I., Hlushko A.V., R.A. Zheldakova, Shkumatov V.M. Redox-Active Silver(I) Complexes with Sterically Hindered 1,2-Dihydroxybenzene Derivatives: Reduction of Cytochrome c and Antimicrobial Activity  // Cytochromes b and c: Biochemical Properties, Biological Functions and Electrochemical Analysis Chapters / Ed. R. Thom. – Hauppauge, New York: Nova Science Publisher’s, 2014.  P.121–172.
  9. Faletrov Y.V., Bialevich K.I., Edimecheva I.P., Kostsin D.G., Rudaya E.V., Slobozhanina E.I., Shkumatov V.M. 22-NBD-cholesterol as a novel fluorescent substrate for cholesterol-converting oxidoreductases // J. Steroid Biochem. Mol. Biol. 2013. Vol. 134.  P.59-66.
  10. Faletrov Y.V., Frolova N.S., Hlushko H.V., Rudaya E.V., Edimecheva I.P., Mauersberger S., Shkumatov V.M. Evaluation of the fluorescent probes Nile Red and 25-NBD-cholesterol as substrates for steroid-converting oxidoreductases using pure enzymes and microorganisms // FEBS J.  2013. Vol. 280. P.3109-3119
  11. Ya.V. Faletrov et al. // FEBS J. – 2013. – Vol.  280. – P. 3109-3119.