image of the person

Yaroslav Faletrov

EN | RU

Head of Laboratory
PhD (Chemistry)
Docent (Associate professor)

Department: Laboratory of biochemistry of drugs
e-mail: yaroslav82@tut.by
Phone: +375 (17) 200-82-72

 

h-index (Scopus) – 8,
h-index (Web of Science) – 6,
h-index (Google scholar) – 12,
https://scholar.google.ru/citations?user=S2xopSIAAAAJ&hl=ru
 
Subject and Class of Degrees

  • 2013 – PhD in biochemistry, Institute of Bioorganic Chemistry, National Academy of Science, Belarus;
  • 1999-2004 – Chemistry Department, Belarusian State University (diploma -  pharm. chemistry);
  • 2005  Degree of Master of Natural Sciences. Chemistry Department, Belarusian State University, Minsk, Belarus.

Career

  • Since 2024     Head of the laboratory of Biochemistry of Drugs, RI PCP BSU;
  • 2017-2024      Leading researcher in the Laboratory of Biochemistry of Drugs, RI PCP BSU;
  • 2014-2017      Senior researcher in the Laboratory of Biochemistry of Drugs, RI PCP BSU;
  • 2012-2014      Researcher in the Laboratory of Biochemistry of Drugs, RI PCP BSU;
  • 2005-2012      Junior researcher in the Laboratory of Biochemistry of Drugs, Research Institute for Physical Chemical Problems (RI PCP BSU).      

Current research activity, main achievements

Docking-based virtual screening, fluorescent and steroidal compounds; design, synthesis and evaluation their physic-chemical and biological properties.
 
List of Selected Publications

  1. Panada  J., Klopava V., Kulahava T., Koran S., Faletrov Y., Frolova N., Fomina E., Shkumatov V.  Differential induction of C6 glioma apoptosis and autophagy by 3β-hydroxysteroid-indolamine conjugates // Steroids. 2023. V. 200. 109326. https://doi.org/10.1016/j.steroids.2023.109326
  2. Gvozdev M.Y., Loginova N.V., Ksendzova G.A., Osipovich N.P., Koval’chuk-Rabchinskaya T.V., Faletrov Y.V., Khodosovskaya A.M., Evtushenkov A.N. Bismuth(III) Complexes with Phenolic Schiff Bases: Synthesis, Characterization, Interaction with Biomolecules, Antioxidant and Antimicrobial Activity // Medicinal Chemistry. 2022. Nov.18. (DOI: 10.2174/1573406419666221118104019) (Shāriqah, United Arab Emirates) (IF 2.329)
  3. Masiuk U.S., Faletrov Y.V., Kananovich D.G., Mineyeva I.V. Stereodivergent Assembly of 2,6- cis- and - Trans-Tetrahydropyrans via Base-Mediated Oxa-Michael Cyclization: The Key Role of the TMEDA Additive // Journal of Organic Chemistry. 2022. DOI: 10.1021/acs.joc.2c02382 (IF 4.354)
  4. Sluchanko N.N., Slonimskiy Y.B., Egorkin N.A., Varfolomeeva L.A., Faletrov Y.V., Moysenovich A.M., Parshina E.Y., Friedrich T., Maksimov E.G., Boyko K.M., Popov V.O. Silkworm carotenoprotein as an efficient carotenoid extractor, solubilizer and transporter // International Journal of Biological Macromolecules. 2022. 223. pp. 1381-1393. DOI: 10.1016/j.ijbiomac.2022.11.093 (IF 8.025)
  5. Sluchanko N.N., Slonimskiy Y.B., Egorkin N.A., Varfolomeeva L.A., Kleymenov S.Yu., Minyaev M.E., Faletrov Y.V., Moysenovich A.M., Parshina E.Yu., Friedrich T., Maksimov E.G., Boyko K.M., Popov V.O. Structural basis for the carotenoid binding and transport function of a START domain // Structure. 2022. 30 (12). рр. 1647-1659.e4. DOI: 10.1016/j.str.2022.10.007.  (IF 5.006)
  6. Faletrov Y.V., Staravoitava V.A., Dudko A.R., Shkumatov V.M.  Application of docking-based inverse high throughput virtual screening to found phytochemical covalent inhibitors of SARS-CoV-2 main protease, NSP12 and NSP16, 21 March 2022, PREPRINT (Version 1) available at Research Square (https://doi.org/10.21203/rs.3.rs-1456627/v1)
  7. Mineyeva I.V., Faletrov Y.V., Staravoitava V.A., Shkumatov V.M. Synthesis and In Silico Prediction of Biological Activity and Acute Toxicity of [1,3]Thiazolo[3,2-a]pyrimidines Containing Aliphatic Aldehyde Fragments // Russian Journal of Organic Chemistry. 2022. 58 (7). pp. 941-958. DOI: 10.1134/S1070428022070028
  8. Mineyeva, I.V., Faletrov, Y.V., Staravoitava, V.A., Shkumatov, V.M. New 1,4-Dihydropyridines. Optimization of the Synthesis and In Silico Analysis of Biological Activity // Russian Journal of Organic Chemistry. 2022. 58 (3). pp. 268-281. DOI: 10.1134/S1070428022030034
  9. Panada J.U., Klopava V.A., Kulahava T.A., Faletrov Y.V., Frolova N.S., Koran S.V., Fomina E.G., Shkumatov V.M. Influence of N-alkynylaminosteroids on mitochondria function and autophagy in glioma cells // Biomeditsinskaya Khimiya. 2022. 68 (2). pp. 126-133. DOI: 10.18097/PBMC20226802126
  10. Zamalutdinova S.V., Isaeva L.V., Zamalutdinov A.V., Faletrov Y.V., Rubtsov M.A., Novikova L.A. Analysis of Activity of Human Steroidogenic Acute Regulatory Protein (STARD1) Expressed in Escherichia coli Cells //  Biochemistry (Moscow). 2022. 87 (9). pp. 1015-1020. DOI: 10.1134/S0006297922090127
  11. Faletrov Y.V., Maliugin V.O., Frolova N.S., Shkumatov V.M. In silico evaluation of new affine interactions of methylcoumarin with cytochromes P450 // Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 2022. 58 (2). pp. 186-190. DOI: 10.29235/1561-8331-2022-58-2-186-190
  12. Faletrov Y.V., Pozniak H.I., Yakovets P.S., Frolova N.S., Shkumatov V.M. New lipophilic conjugates of fluorescent nbd-piperazine: synthesis, in silico interactions with lipid bilayer and cytochromes P450 // Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 2022. 58 (1). pp. 62-67. DOI: 10.29235/1561-8331-2022-58-1-62-67
  13. Panada J, Klopava V, Kulahava T, Frolova N, Faletrov Y, Shkumatov V. New 3(3-hydroxysteroid-in dolamine conjugates: Design, synthesis and inhibition of C6 glioma cell proliferation // Steroids.  2020.  Vol. 164. P. 108728. doi: 10.1016/j.steroids.2020.108728. 
  14. Ya.V. Faletrov et al. // Chem Phys Lipids. –  2020 – Vol. – P.104850.
  15. K.V. Tugaeva et al. // Biochem. Biophys. Res. Commun. – 2018. – 497. – P. 58-64.
  16. Faletrov Y.V., Efimova V.S., Horetski M.S., Tugaeva K.V., Frolova N.S., Lin Q., Isaeva L.V., Rubtsov M.A., Sluchanko N.N., Novikova L.A., Shkumatov V.M. New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells // Chem. Phys. Lipids. 2020. Vol. 227. P. 104850. doi: 10.1016/j.chemphyslip.2019.104850.
  17. Tugaeva K.V., Faletrov Y.V., Allakhverdiev E.S., Shkumatov V.M., Maksimov E.G., Sluchanko N.N. Effect of the NBD-group position on interaction of fluorescently-labeled cholesterol analogues with human steroidogenic acute regulatory protein STARD1 // Biochem. Biophys. Res. Commun.  2018.  Vol. 497. P. 58-64.
  18. Faletrov Y., Brzostek A., Plocinska R., Dziadek J., Rudaya E., Edimecheva I., Shkumatov V. Uptake and metabolism of fluorescent steroids by mycobacterial cells // Steroids.  2017. Vol.117. P.29-37.
  19. N.V. Loginova et al. // Polyhedron. – 2015. – Vol. 88. – P. 125–137.
  20. Loginova N.V., Koval’chuk T.V., Osipovich N.P., Faletrov Y.V., Halauko Yu.S.,. Polozov G.I, Gres’ A.T., Harbatsevich H.I., Hlushko A.V., R.A. Zheldakova, Shkumatov V.M. Redox-Active Silver(I) Complexes with Sterically Hindered 1,2-Dihydroxybenzene Derivatives: Reduction of Cytochrome c and Antimicrobial Activity  // Cytochromes b and c: Biochemical Properties, Biological Functions and Electrochemical Analysis Chapters / Ed. R. Thom. – Hauppauge, New York: Nova Science Publisher’s, 2014.  P.121–172.
  21. Faletrov Y.V., Bialevich K.I., Edimecheva I.P., Kostsin D.G., Rudaya E.V., Slobozhanina E.I., Shkumatov V.M. 22-NBD-cholesterol as a novel fluorescent substrate for cholesterol-converting oxidoreductases // J. Steroid Biochem. Mol. Biol. 2013. Vol. 134.  P.59-66.
  22. Faletrov Y.V., Frolova N.S., Hlushko H.V., Rudaya E.V., Edimecheva I.P., Mauersberger S., Shkumatov V.M. Evaluation of the fluorescent probes Nile Red and 25-NBD-cholesterol as substrates for steroid-converting oxidoreductases using pure enzymes and microorganisms // FEBS J.  2013. Vol. 280. P.3109-3119
  23. Ya.V. Faletrov et al. // FEBS J. – 2013. – Vol.  280. – P. 3109-3119.