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Iryna Mineyeva (Mineeva)

EN | RU

Researcher
Doctor of Sciences (Chemistry)
Docent (Associate professor)

Department: Laboratory of chemistry of free radical processes
e-mail: MineyevaIV@bsu.by, i.mineyeva@yandex.ru

  • h-index (Scopus) – 9
  • h-index (Web of Science) – 9
  • h-index (Google Scholar) – 9

https://scholar.google.com/citations?user=w1WYkgMAAAAJ&hl=ru&oi=sra

Subject and Class of Degrees:

  • 2000-2005 – Faculty of Chemistry, Belarusian State University;
  • 2005-2008 – PhD courses, Belarusian State University;
  • 2011 – Doctoral Degree in Сhemistry; Ph.D. thesis at the Institute of Bioorganic chemistry of the National Academy of Sciences of the Republic of Belarus. Thesis title: “Synthesis of bioactive compounds via the conversion of functionally substituted cyclopropanols into allyl halides with an isopentane carbon chain”
  • 2018-2022 – Doctoral studies, Belarusian State University;
  • 2023 – Doctor of Science degree. Thesis title: “2-Substituted functionalized allyl bromides in the synthesis of natural bioactive compounds and their fragments”.

Career:

  • 2005 – Assistant of the Department of Organic Chemistry, Engineer of the Research Laboratory of Organoelement chemistry of the Department of Organic Chemistry, Belarusian State University;
  • 2011 – Senior Lecturer, Department of Organic Chemistry, Belarusian State University;
  • 2012 – Associate Professor, Department of Organic Chemistry, Belarusian State University;
  • Since 2024 – Professor, Department of Organic Chemistry, Belarusian State University Researcher; part-time (since 2023) Researcher of the Research Institute for Physical Chemical Problems (RI PCP BSU).

Current research activity:

  • Directed synthesis of bioactive and natural compounds, low-molecular bioregulators;
  • Chemistry of small cycles;
  • Chemistry of heterocyclic compounds;
  • Metal complex catalysis;
  • Modern methods of organic synthesis;
  • Chemical military toxicology;
  • Biochemistry of drugs;
  • Bioinformatics, calculation methods;
  • Organoelement chemistry;
  • New methods in synthesis.

List of the selected publications:

  1. Masiuk U.S., Faletrov Ya.V., Kananovich D.G., Mineyeva I.V. Stereodivergent Assembly of 2,6-cis- and -trans-Tetrahydropyrans via Base-Mediated Oxa-Michael Cyclization: The Key Role of the TMEDA Additive // The Journal of Organic Chemistry. 2023 88 (1), 355-370. https://doi.org/10.1021/acs.joc.2c02382
  2. Mineyeva I.V. 2-Substituted Allyl Bromides as Electrophilic and Nucleophilic Building Blocks for 1,3-Dicarbonyl Compounds and Their Use in the Synthesis of Heterocycles // Russ J Org Chem 58, 1200–1212 (2022). https://doi.org/10.1134/S1070428022090032
  3. Mineyeva I.V., Shkumatov V.M. S-Functionalization of 3,4-Dihydropyrimidine-2(1H)-thiones with 2-Substituted Allyl Bromides // Russ J Org Chem. 58, 1233–1241 (2022). https://doi.org/10.1134/S1070428022090068
  4. Mineyeva I.V., Faletrov Y.V., Staravoitava V.A., Shkumatov V.M. Synthesis and In Silico Prediction of Biological Activity and Acute Toxicity of [1,3]Thiazolo[3,2-a]pyrimidines Containing Aliphatic Aldehyde Fragments // Russ J Org Chem. 58, 941–958 (2022). https://doi.org/10.1134/S1070428022070028
  5. Mineyeva I.V. α,β-Unsaturated β-Methyl-δ-lactones in Nitrile Oxide Cycloaddition Reactions. Synthesis of Saturated Lactones and Lactams // Russ J Org Chem. 58, 765–779 (2022). https://doi.org/10.1134/S1070428022060033
  6. Lamekina Y.P., Kulahava T.A., Shumski V.A., Mineyeva I.V. Allylation of Ketones with Methyl 3-(Bromomethyl)but-3-enoate. Synthesis of Bioactive Unsaturated Lactones Based on Benzo[f]coumarin and Its Derivatives // Russ J Org Chem. 58, 751–764 (2022). https://doi.org/10.1134/S1070428022060021
  7. Mineyeva I.V., Faletrov Y.V., Starovoitova V.A., Shkumatov V.M. New 1,4-Dihydropyridines. Optimization of the Synthesis and In Silico Analysis of Biological Activity. Russ J Org Chem 58, 268–281 (2022). https://doi.org/10.1134/S1070428022030034
  8. Mineeva I.V., Faletrov Y.V., Starovoytova V.A., Shkumatov V.M. Synthesis of new thiazolo[3,2-a]pyrimidine derivatives and in silico analysis of their bioactivity // Proceedings of the National Academy of Sciences of Belarus, Chemical Series, 2022; 258:186 https://doi.org/10.29235/1561-8331-2021-57-4-456-462
  9. Masyuk V.S., Kozyrkov Y.Y., Mineeva I.V. Synthesis of α,β-Unsaturated Aldehydes with an (E)-Trisubstituted Double Bond via Ring Opening of Cyclopropanols // Russ J Org Chem. 57, 1563–1574 (2021). https://doi.org/10.1134/S1070428021100018
  10. Mineeva I.V. Diastereoselective Allylation of α-Hydroxy Schiff Bases with 2-Substituted Functionalized Allyl Bromides // Russ J Org Chem. 57, 1435–1447 (2021). https://doi.org/10.1134/S1070428021090086
  11. Masiuk U.S., Mineyeva I.V., Kananovich D.G. Highly Diastereoselective Chelation-Controlled 1,3-anti-Allylation of (S)-3-(Methoxymethyl)hexanal Enabled by Hydrate of Scandium Triflate // Symmetry. 2021; 13(3):470. https://doi.org/10.3390/sym13030470
  12. Snetkov D.A., Mineeva I.V. Methyl 3-(Bromomethyl)but-3-enoate and Methyl 3-[(Tributylstannyl)methyl]but-3-enoate in Azomethine Allylation Reactions // Russ J Org Chem. 56, 1327–1335 (2020). https://doi.org/10.1134/S1070428020080011
  13. Mineeva I.V. Synthesis of the Mealworm Tenebrio molitor L. Pheromone // Russ J Org Chem. 56, 994–1000 (2020). https://doi.org/10.1134/S1070428020060056
  14. Mineeva I.V. Allylation of (R)-2,3-O-Cyclohexylideneglyceraldehyde with Methyl 3-(Bromomethyl)but-3-enoate. Methyl 3-{(2S)-2-[(2R)-1,4-Dioxaspiro[4.5]dec-2-yl]-2-hydroxyethyl}but-3-enoate as a Convenient Universal Building Block for the Synthesis of Key Fragments of Bioactive Compounds // Russ J Org Chem. 55, 1112–1123 (2019). https://doi.org/10.1134/S1070428019080098
  15. Mineeva I.V. Synthesis of (2S)-4-Methyl- and (2S)-4-Methyl-6-oxo-3,6-dihydro-2H-pyran-2-carbaldehydes as Precursors to C22–C27 Fragments of Fijianolides and Their Synthetic Analogs // Russ J Org Chem. 54, 1341–1349 (2018). https://doi.org/10.1134/S1070428018090130
  16. Mineyeva I.V. Functionalized 2-Substituted Allyl Bromides in the Barbier Allylation of (R)-2,3-O-Isopropylideneglyceraldehyde. Synthesis of the C8–C17, C8–C18, and C5–C17 Building Blocks of Laulimalides and Their Synthetic Analogs // Russ J Org Chem. 55, 530–539 (2019). https://doi.org/10.1134/S1070428019040195
  17. Masyuk V.S., Mineeva I.V. Synthesis of phenyl analog of retinoic acid methyl ester proceeding from 3-(bromomethyl)but-3-enal diethylaceta // Russ J Org Chem. 53, 1642–1650 (2017). https://doi.org/10.1134/S1070428017110045
  18. Mineeva I.V. New 2-substituted functionalized allyl halides in the synthesis of fragments of amphidinolides B, D, G, H, and L // Russ J Org Chem. 53, 433–444 (2017). https://doi.org/10.1134/S1070428017030204
  19. Mineeva I.V. Cyclopropanol intermediates in the synthesis of the C5–C14 fragment of laulimalides // Russ J Org Chem. 52, 355–367 (2016). https://doi.org/10.1134/S1070428016030118
  20. Masyuk V.S., Mineeva I.V. Synthesis of β-(2,2-diethoxyethyl)-substituted (allyl)tributylstannane and its application to asymmetric allylation // Russ J Org Chem. 52, 178–185 (2016). https://doi.org/10.1134/S1070428016020020
  21. Mineeva I.V. (3S)-4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbutan-1-ol—A universal building block for the synthesis of principal fragments of amphidinolides G and H // Russ J Org Chem. 52, 104–112 (2016). https://doi.org/10.1134/S1070428016010206
  22. Mineeva I.V. New approach to the synthesis of macrocyclic core of cytotoxic lactone (+)-neopeltolide. Synthesis of C7–C14 segment basing on cyclopropanol intermediates // Russ J Org Chem. 51, 1061–1070 (2015). https://doi.org/10.1134/S1070428015080023
  23. Mineeva I.V. Synthesis of ethyl (2E,5S)-7-{[tert-butyl(dimethyl)silyloxy]-methyl}-5-methylocta-2,7-dienoate, a universal C7–C14 building block for the preparation of amphidinolides B, D, G, H, and L. // Russ J Org Chem. 51, 920–930 (2015). https://doi.org/10.1134/S1070428015070052
  24. Mineeva I.V. Asymmetric syntheses of the lactone core of tetrahydrolipstatin and tetrahydroesterastin and of the oriental hornet Vespa Orientalis pheromone // Russ J Org Chem. 51, 842–848 (2015). https://doi.org/10.1134/S1070428015060044
  25. Mineeva I.V. Cyclopropanol methodology in the synthesis of (4R)- and (4S)-4-methyltetrahydro-2H-pyran-2-ones. Application in the synthesis of insect pheromones with methyl-branched carbon skeleton // Russ J Org Chem. 51, 341–351 (2015). https://doi.org/10.1134/S1070428015030094
  26. Kovalenko V.N., Mineeva I.V. Cyclopropane intermediates in the synthesis of chiral alcohols with methyl-branched carbon skeleton. Application in the synthesis of insect pheromones // Russ J Org Chem. 50, 934–942 (2014). https://doi.org/10.1134/S1070428014070033
  27. Mineyeva I.V. (5S)-5-hydroxy-3-methylidenehexanoate as key intermediate in synthesis of tetrahydrolipstatin and pheromone of oriental hornet Vespa Orientalis // Russ J Org Chem. 50, 1558–1561 (2014). https://doi.org/10.1134/S1070428014110037
  28. Mineyeva I.V., Masyuk V.S., Kovalenko V.N. et al. (4S,6R)-4-methyl-6-pentyltetrahydro-2H-pyran-2-one as an efficient intermediate in the preparation of chiral building blocks with methyl-branched carbon skeleton. Application to the synthesis of bioactive compounds // Russ J Org Chem. 50, 1621–1627 (2014). https://doi.org/10.1134/S1070428014110141
  29. Mineeva I.V. (3S,5R)-6-(benzyloxy)-3-methylhexane-1,5-diol in the synthesis of insect pheromones with methyl-branched carbon chain and of amphidinolide L C7–C14 fragment // Russ J Org Chem. 50, 168–174 (2014). https://doi.org/10.1134/S1070428014020043
  30. Mineeva I.V. New asymmetric synthesis of a pheromone component of the shield bug Cantao Parentum // Russ J Org Chem. 50, 398–405 (2014). https://doi.org/10.1134/S1070428014030178
  31. Mineeva I.V. Asymmetric synthesis of valilactone // Russ J Org Chem. 50, 100–104 (2014). https://doi.org/10.1134/S1070428014010199
  32. Mineeva I.V. Asymmetric synthesis of (+)-(S)-Massoia lactone, pheromone of Idea leuconoe. Formal total synthesis of valilactone and lachnelluloic acid // Russ J Org Chem. 49, 1647–1654 (2013). https://doi.org/10.1134/S1070428013110146
  33. Mineeva I.V. Methyl (5R)-5-hydroxy-3-methylidenedecanoate as a promising building block in asymmetric syntheses of bioactive natural compounds // Russ J Org Chem. 49, 979–985 (2013). https://doi.org/10.1134/S107042801307004X
  34. Mineeva I.V. Methyl (3R,5R)-3,5-dihydroxydecanoate in the asymmetric synthesis of Idea Leuconoe pheromone and formal syntheses of (+)-(3R,5R)-3-hydroxydecano-5-lactone, verbalactone, and Tolypothrix pentaether // Russ J Org Chem. 49, 838–842 (2013). https://doi.org/10.1134/S1070428013060067
  35. Mineeva I.V. Enantioselective synthesis of (+)-(S)-7,8-dihydrokavain and (4R,6R)-4-hydroxy-6-(2-phenylethyl)tetrahydro-2H-pyran-2-one, lactone analog of compactin and mevinolin // Russ J Org Chem. 49, 712–716 (2013). https://doi.org/10.1134/S1070428013050138
  36. Mineeva I.V. (4R,6R)-6-(hydroxymethyl)-4-methyltetrahydro-2H-pyran-2-one in the synthesis of polyfunctional compounds with the methyl-branched carbon skeleton // Russ J Org Chem. 49, 253–258 (2013). https://doi.org/10.1134/S1070428013020127
  37. Mineeva I.V. Asymmetric synthesis of (−)-(R)-massoia lactone, (R)-δ-decalactone, and (+)-(3R,5R)-3-hydroxydecano-5-lactone. Formal synthesis of verbalactone // Russ J Org Chem. 48, 977–981 (2012). https://doi.org/10.1134/S1070428012070159
  38. Mineeva I.V., Kulinkovich O.G. Preparation of 3-bromomethyl-3-butenal diethylacetal and its conversion into isoprenoid aldehydes derivatives // Russ J Org Chem. 45, 1623–1632 (2009). https://doi.org/10.1134/S1070428009110086
  39. Mineeva I.V., Kulinkovich O.G. Synthesis of methyl 3-bromomethylbut-3-enoate and its reactions with aldehydes and tributylchlorostannane in the presence of zinc // Russ J Org Chem. 44, 1261–1266 (2008). https://doi.org/10.1134/S1070428008090029