image of the person

Yaroslav Faletrov

EN | RU

Head of department
PhD (Chemistry)
Docent (Associate professor)

Department:
e-mail: YaroslavFaletrov@bsu.by
Phone: +375 (17) 270-27-72

 

h-index (Scopus) – 10,
h-index (Web of Science) – 6,
h-index (Google scholar) – 14,
https://scholar.google.ru/citations?user=S2xopSIAAAAJ&hl=ru
 
Subject and Class of Degrees

  • 2018 – Docent;
  • 2013 – PhD in biochemistry, Institute of Bioorganic Chemistry, National Academy of Science, Belarus;
  • 2005 – Degree of Master of Natural Sciences. Chemistry Department, Belarusian State University, Minsk, Belarus.

Current research activity, main achievements

Docking-based virtual screening, fluorescent and steroidal compounds; design, synthesis and evaluation their physic-chemical and biological properties.
 
List of Selected Publications

  1. Bardakova K., Faletrov Y., Epifanov E., Minaev N., Kuryanova A., Kaplin V., Frolova A., Kholkhoev B., Piskun Y., Bikmulina P., Shpichka A.,  Kostjuk S., Timashev P. Hydrophobic ciprofloxacin derivatives as dual-functional photoinitiators for photocurable polylactide scaffolds in treatment of infected bone defects // Biomater. Sci., 2025. https://doi.org/10.1039/D5BM01345C
  2. Zamalutdinova S.V., Isaeva L.V., Faletrov Y.V., Eroshchenko N.N., Kirushin A.N., Tashlitsky V.N., Rubtsov M.A., Novikova L.A. Using of transporter proteins to improve the uptake efficiency of hydrophobic compounds by Escherichia coli: a coordinated synthesis of START protein and P450scc system proteins to enhance cholesterol biotransformation // Bioresour. Bioprocess. 2025, 12, 77. https://doi.org/10.1186/s40643-025-00909-1 (IF 5.1)
  3. Gvozdev M.Y., Turomsha I.S., Savich V.V., Faletrov Y.V., Sidarenka A.V., Shkumatov V.M., Loginova N.V. Sterically hindered phenolic derivatives: effect on the production of Pseudomonas aeruginosa virulence factors, high-throughput virtual screening and ADME properties prediction // Archives of Microbiology. 2024. 206 (3). 91. https://doi.org/10.1007/s00203-023-03827-y
  4. Panada  J., Klopava V., Kulahava T., Koran S., Faletrov Y., Frolova N., Fomina E., Shkumatov V.  Differential induction of C6 glioma apoptosis and autophagy by 3β-hydroxysteroid-indolamine conjugates // Steroids. 2023. V. 200. 109326. https://doi.org/10.1016/j.steroids.2023.109326
  5. Gvozdev M.Y., Loginova N.V., Ksendzova G.A., Osipovich N.P., Koval’chuk-Rabchinskaya T.V., Faletrov Y.V., Khodosovskaya A.M., Evtushenkov A.N. Bismuth(III) Complexes with Phenolic Schiff Bases: Synthesis, Characterization, Interaction with Biomolecules, Antioxidant and Antimicrobial Activity // Medicinal Chemistry. 2022. Nov.18. (DOI: 10.2174/1573406419666221118104019) (Shāriqah, United Arab Emirates) (IF 2.329)
  6. Masiuk U.S., Faletrov Y.V., Kananovich D.G., Mineyeva I.V. Stereodivergent Assembly of 2,6- cis- and - Trans-Tetrahydropyrans via Base-Mediated Oxa-Michael Cyclization: The Key Role of the TMEDA Additive // Journal of Organic Chemistry. 2022. DOI: 10.1021/acs.joc.2c02382 (IF 4.354)
  7. Sluchanko N.N., Slonimskiy Y.B., Egorkin N.A., Varfolomeeva L.A., Faletrov Y.V., Moysenovich A.M., Parshina E.Y., Friedrich T., Maksimov E.G., Boyko K.M., Popov V.O. Silkworm carotenoprotein as an efficient carotenoid extractor, solubilizer and transporter // International Journal of Biological Macromolecules. 2022. 223. pp. 1381-1393. DOI: 10.1016/j.ijbiomac.2022.11.093 (IF 8.025)
  8. Sluchanko N.N., Slonimskiy Y.B., Egorkin N.A., Varfolomeeva L.A., Kleymenov S.Yu., Minyaev M.E., Faletrov Y.V., Moysenovich A.M., Parshina E.Yu., Friedrich T., Maksimov E.G., Boyko K.M., Popov V.O. Structural basis for the carotenoid binding and transport function of a START domain // Structure. 2022. 30 (12). рр. 1647-1659.e4. DOI: 10.1016/j.str.2022.10.007.  (IF 5.006)
  9. Faletrov Y.V., Staravoitava V.A., Dudko A.R., Shkumatov V.M.  Application of docking-based inverse high throughput virtual screening to found phytochemical covalent inhibitors of SARS-CoV-2 main protease, NSP12 and NSP16, 21 March 2022, PREPRINT (Version 1) available at Research Square (https://doi.org/10.21203/rs.3.rs-1456627/v1)
  10. Mineyeva I.V., Faletrov Y.V., Staravoitava V.A., Shkumatov V.M. Synthesis and In Silico Prediction of Biological Activity and Acute Toxicity of [1,3]Thiazolo[3,2-a]pyrimidines Containing Aliphatic Aldehyde Fragments // Russian Journal of Organic Chemistry. 2022. 58 (7). pp. 941-958. DOI: 10.1134/S1070428022070028
  11. Mineyeva, I.V., Faletrov, Y.V., Staravoitava, V.A., Shkumatov, V.M. New 1,4-Dihydropyridines. Optimization of the Synthesis and In Silico Analysis of Biological Activity // Russian Journal of Organic Chemistry. 2022. 58 (3). pp. 268-281. DOI: 10.1134/S1070428022030034
  12. Panada J.U., Klopava V.A., Kulahava T.A., Faletrov Y.V., Frolova N.S., Koran S.V., Fomina E.G., Shkumatov V.M. Influence of N-alkynylaminosteroids on mitochondria function and autophagy in glioma cells // Biomeditsinskaya Khimiya. 2022. 68 (2). pp. 126-133. DOI: 10.18097/PBMC20226802126
  13. Zamalutdinova S.V., Isaeva L.V., Zamalutdinov A.V., Faletrov Y.V., Rubtsov M.A., Novikova L.A. Analysis of Activity of Human Steroidogenic Acute Regulatory Protein (STARD1) Expressed in Escherichia coli Cells //  Biochemistry (Moscow). 2022. 87 (9). pp. 1015-1020. DOI: 10.1134/S0006297922090127
  14. Faletrov Y.V., Maliugin V.O., Frolova N.S., Shkumatov V.M. In silico evaluation of new affine interactions of methylcoumarin with cytochromes P450 // Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 2022. 58 (2). pp. 186-190. DOI: 10.29235/1561-8331-2022-58-2-186-190
  15. Faletrov Y.V., Pozniak H.I., Yakovets P.S., Frolova N.S., Shkumatov V.M. New lipophilic conjugates of fluorescent nbd-piperazine: synthesis, in silico interactions with lipid bilayer and cytochromes P450 // Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 2022. 58 (1). pp. 62-67. DOI: 10.29235/1561-8331-2022-58-1-62-67
  16. Panada J, Klopava V, Kulahava T, Frolova N, Faletrov Y, Shkumatov V. New 3(3-hydroxysteroid-in dolamine conjugates: Design, synthesis and inhibition of C6 glioma cell proliferation // Steroids.  2020.  Vol. 164. P. 108728. doi: 10.1016/j.steroids.2020.108728. 
  17. Ya.V. Faletrov et al. // Chem Phys Lipids. –  2020 – Vol. – P.104850.
  18. K.V. Tugaeva et al. // Biochem. Biophys. Res. Commun. – 2018. – 497. – P. 58-64.
  19. Faletrov Y.V., Efimova V.S., Horetski M.S., Tugaeva K.V., Frolova N.S., Lin Q., Isaeva L.V., Rubtsov M.A., Sluchanko N.N., Novikova L.A., Shkumatov V.M. New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells // Chem. Phys. Lipids. 2020. Vol. 227. P. 104850. doi: 10.1016/j.chemphyslip.2019.104850.
  20. Tugaeva K.V., Faletrov Y.V., Allakhverdiev E.S., Shkumatov V.M., Maksimov E.G., Sluchanko N.N. Effect of the NBD-group position on interaction of fluorescently-labeled cholesterol analogues with human steroidogenic acute regulatory protein STARD1 // Biochem. Biophys. Res. Commun.  2018.  Vol. 497. P. 58-64.
  21. Faletrov Y., Brzostek A., Plocinska R., Dziadek J., Rudaya E., Edimecheva I., Shkumatov V. Uptake and metabolism of fluorescent steroids by mycobacterial cells // Steroids.  2017. Vol.117. P.29-37.
  22. N.V. Loginova et al. // Polyhedron. – 2015. – Vol. 88. – P. 125–137.
  23. Loginova N.V., Koval’chuk T.V., Osipovich N.P., Faletrov Y.V., Halauko Yu.S.,. Polozov G.I, Gres’ A.T., Harbatsevich H.I., Hlushko A.V., R.A. Zheldakova, Shkumatov V.M. Redox-Active Silver(I) Complexes with Sterically Hindered 1,2-Dihydroxybenzene Derivatives: Reduction of Cytochrome c and Antimicrobial Activity  // Cytochromes b and c: Biochemical Properties, Biological Functions and Electrochemical Analysis Chapters / Ed. R. Thom. – Hauppauge, New York: Nova Science Publisher’s, 2014.  P.121–172.
  24. Faletrov Y.V., Bialevich K.I., Edimecheva I.P., Kostsin D.G., Rudaya E.V., Slobozhanina E.I., Shkumatov V.M. 22-NBD-cholesterol as a novel fluorescent substrate for cholesterol-converting oxidoreductases // J. Steroid Biochem. Mol. Biol. 2013. Vol. 134.  P.59-66.
  25. Faletrov Y.V., Frolova N.S., Hlushko H.V., Rudaya E.V., Edimecheva I.P., Mauersberger S., Shkumatov V.M. Evaluation of the fluorescent probes Nile Red and 25-NBD-cholesterol as substrates for steroid-converting oxidoreductases using pure enzymes and microorganisms // FEBS J.  2013. Vol. 280. P.3109-3119
  26. Ya.V. Faletrov et al. // FEBS J. – 2013. – Vol.  280. – P. 3109-3119.