НИИ ФХП БГУ

Research Institute for Physical Chemical Problems
of the Belarusian State University

Samovich Sviatlana



Senior Researcher
Ms, Ph.D.
 
h-index (Scopus) 3
 h-index (Web of Science) 3
h-index (Google science) 4 (https://scholar.google.com/citations?user=sKUaVZkAAAAJ&hl=ru&oi=ao )
 
Education
2009 – graduated Faculty of Chemistry, Belarusian State University (BSU), Minsk, Belarus;
2013 – defended Ph.D. in High Energy Chemistry, Department of Radiation Chemistry and Chemical-Pharmaceutical Technologies, Faculty of Chemistry, BSU.
 
Career
  • 2010-2012 – junior researcher of the laboratory of Chemistry of Free-Radical Processes of the Research Institute for Physical and Chemical Problems, BSU, Minsk;
  • 2013-2014 – researcher of the laboratory of Chemistry of Free-Radical Processes of the Research Institute for Physical and Chemical Problems, BSU, Minsk;
  • From 2015 – senior researcher of the laboratory of Chemistry of Free-Radical Processes of the Research Institute for Physical and Chemical Problems, BSU, Minsk;
  • 2014–2016 – lecturer at the Department of Radiation Chemistry and Chemical-Pharmaceutical Technologies, Faculty of Chemistry, BSU, Minsk (Part time);
  • From 2016 – assistant Professor at the Department of Radiation Chemistry and Chemical-Pharmaceutical Technologies, Faculty of Chemistry, BSU, Minsk (Part time).
 
Current research activity, main achievements

According to the scientific results, for the first time, new radical-regulatory properties of aromatic alcohols, aldehydes and acids were discovered. Benzaldehyde and its derivatives were shown to oxidize α-hydroxyl containing carbon-centered radicals, while phenylpropanoids added these radicals to the carbonyl group or the –С=С– double bond conjugated with the aromatic ring. Aromatic aldehydes and acids were found to inhibit free-radical processes taking place on dehydration of ethylene glycol, demethoxylation of its monomethyl ether, dephosphorylation of glycero-1-phosphate, and O-glycoside bond rupture in methyl glycosides. Data in this area are necessary for better understanding molecular mechanisms responsible for pharmacological activity manifested by aromatic alcohols, aldehydes and acids in treatment of diseases caused by activation of free-radical processes in a living organism.
A patent have been received (BY 1700) for discovery of compound having antiviral activity towards Herpes simplex type I viruses. A certificate of practical utilization of the study results in the educational process has been obtained.
From 2012 – member of Federation of European Biochemical Societies (FEBS);
2013, 2014 – member of the organizing committee at the XI and XII International Conferences «Medical and Social Ecology of Personality», Minsk, Belarus.
2015, 2017 – member of the organizing committee at the International Conference «Free radicals in chemistry and life», Minsk, Belarus.
From 2017 – member of Belarusian Society of Biochemists and Molecular Biologists;
 
Awards
  • Grants by the Belarusian State University for supporting students, 2011–2012.
  • Grants by the Ministry of Education of the Republic of Belarus for supporting PhD students, 2011–2012.
  • Grants by the Belarusian Republican Foundation for Fundamental Research for supporting young scientists, 2014–2017.
  • Diploma of the laureate of the International Conference of Young Scientists and VII School «Oxidation, oxidative stress and antioxidants» for success in science and active participation, October 2015, Moscow, Russia;
  • 2016, 2017 – financial support of the MOST project (Mobility program for targeted interpersonal contacts) Leipzig and Berlin, Germany.
 
List of the selected publications
 
  1. Effects of curcumin and related compounds on processes involving α-hydroxyethyl radicals / S.D. Brinkevich, N.I. Ostrovskaya, M.E. Parkhach, S.N. Samovich, O.I. Shadyro // Free Rad. Res. – 2012. – Vol. 46, № 3. – P. 295–302.
  2. Interaction of aromatic alcohols, aldehydes and acids with a-hydroxyl-containing carbon-centered radicals: A steady state radiolysis study / S.N. Samovich, S.D. Brinkevich, O.I. Shadyro // Rad. Phys. Chem. – 2013. – Vol. 82, № 1. – P. 35–43.
  3. Radiation-chemical transformations of coumarins in ethanolic solutions / S.N. Samovich, S.D. Brinkevich, I.P. Edimecheva, O.I. Shadyro // Rad. Phys. Chem. – 2014. – Vol. 100, № 1. – P. 13–22.
  4. Synthesis and Antiviral Activity of Hydroxy-Substituted Benzaldehydes and Related Compounds / O.I. Shadyro, V.L. Sorokin, G.A. Ksendzova, O.V. Savinova, S.N. Samovich, N.I. Pavlova, G.I. Polozov, E.I. Boreko // Pharm. Chem. J. – 2016. – Vol. 50, № 3. – P. 156–158.
  5. Effects of quinones and azoles on radiation-induced processes involving hydroxyl-containing carbon-centered radicals / S.N. Samovich, R.L. Sverdlov, S.V. Voitekhovich, Y.V. Grigoriev, O.A. Ivashkevich, O.I. Shadyro // Rad. Phys. Chem. – 2018. – Vol. 144. – P. 308–316.
  6. Effects of hydroxylated benzaldehyde derivatives on radiation-induced reactions involving various organic radicals / G.A. Ksendzova, S.N. Samovich, V.L. Sorokin, O.I. Shadyro // Rad. Phys. Chem. – 2018. – Vol. 146. – P. 115–120.
 
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