НИИ ФХП БГУ

Research Institute for Physical Chemical Problems
of the Belarusian State University

Golub Natalia

Senior researcher of the laboratory sstructural and chemical modification of polysaccharides and drugs based on them of the Belorussian state University Research Institute for Physicochemical Problems.
PhD in chemistry
 
h-index (Scopus)-2
 
Education -  Higher
 
Career:

  • 1976-1978 – senior laboratory assistant of the department of high-molecular compounds of the Belarusian State University;
  • 1978-1980 – junior researcher at the laboratory of physical chemistry of cellulose of the Belorussian state University Research Institute for Physicochemical Problems;
  • 1989-1994 – researcher of the laboratory of physical chemistry and cellulose modification of theBelorussian state University Research Institute for Physicochemical Problems;
  • 1994-1998 – senior researcher of the laboratory of physical chemistry and cellulose modification of the Belorussian state University Research Institute for Physicochemical Problems;
  • 1998-2015 – senior researcher of the pharmaceutical products on the basis of modified polysaccharides of institution of Belarusian state University Research Institute of Physical and Chemical Problems;
  • 2015 and up to the present  –  senior researcher of the laboratory of structural and chemical modification of polysaccharides and drugs based on themof institution of Belarusian State University Research Institute of Physical and Chemical Problems.
 
Current research activity:

Study of the processes of phosphorylation and oxidation of polysaccharides, the investigation of the properties of reaction products, the regularities of sorption of organic substances of basic and zwitterionic nature by phosphate cation exchangers, the development of prolonged dosage forms of biologically active substances.
 
Theselectedpublications:
  1. Kaputskii F.N., Torgashov V.I., Yurkshtovich T.L.,Golub N.V., Ostrovskaya I.L., Alinovskaya V.A.  Sulfation of polysaccharides with sodium pyrosulfate in dimethyl sulfoxide  // Rus. J. Appl. Chem. 2007. Vol. 80. № 10.  P. 1745-1748. 
  2. Kaputskii  F.N., Yurkshtovich N.K., Yurkshtovich T.L., Golub N.V. Kosterova R.I.Preparation and physicochemical and mechanical properties of low-substituted cellulose phosphate fibers  //  Rus. J. Appl. Chem.  2007. Vol. 80. № 7. P. 1135-1139.
  3. Yurkshtovich N.K., Yurkshtovich T.L., Kaputskii F.N., Golub N.V. Kosterova  R.I. Esterification of viscose fibres with orthophosphoric acid and study of their physicochemical and mechanical properties // Fibre Chem., 2007. Vol. 39. № 1. P. 31-36.
  4. Golub N.V., Kosterova R.I.,Alinovskaya V.A.,Beliaev S.A., Yurkshtovich T.L. Synthesis, structure and propertiesof starch phosphates gels // Vestn. BSU. 2008. № 1. P. 29-33 (in rus).
  5. Yurkshtovich N.K., Yurkshtovich T.L., Kaputskii F.N., Golub N.V., Kosterova R.I. Complexing of chromium(III) and aluminum(III) cations with phosphorus-containing cellulose-based fibrous sorbent  // Rus. J. Appl. Chem. 2009. Vol. 82. № 7. P. 1195-1199.  
  6. Yurkshtovich T.L., Golub N.V., Yurkshtovich N.K.,  Alinovskaya V.A.,Kosterova R.I.Synthesis, structure, and physicochemical properties of gel-forming dextran phosphates  // Rus. J. Appl. Chem.  2012. Vol. 85. № 11. P. 1771–1779.
  7. Yurkshtovich T.L.,Bychkovsky P. M., Golub N.V., Alinovskaya V.A., Kosterova R.I., Kladiev A.A., Krasny S.A., Istomin Yu.P., AlexandrovaE.N.,  Reutovich M.Yu, Shmak A.I.Antineoplastic activity of polymer-immobilized prospidin in vivo on the model of M-1 sarcoma and Jensen sarcoma of rats //Rus. J.Biotherapy. 2012. Vol. 11. №  3. P. 59–63 (in rus).
  8. Bychkovsky P.M., Yurkshtovich T.L., Golub N.V., Alinovskaya V.A., Kosterova R.I., Solomevich S.O., Kladiev A.A., Istomin Yu.P., AlexandrovaE.N.,  Krasny S.A., Petrovskaya N,A,, Reutovich M.Yu., Shmak A.I. Preparation and antitumor activity of a gel-forming prospidine formulation // Pharm. Chem. J. 2013. Vol. 47. № 5. P.387-392.
  9. Bychkovsky P.M., Reutovich M.Yu., Istomin Yu.P.,  Alexandrova E.N., Kladiev A.A.,  Shmak A.I., Yurkshtovich T.L., Golub N.V., Alinovskaya V.A., Kosterova R.I., Solomevich S.O., Kvacheva  Z.B. Experimental basis of the use of hydrogel prospidin for intraperitoneal chemotherapy // Oncolog. J. 2013. Vol. 7. No. 3. C. 27-36 (in rus).
  10. Yurkshtovich T.L., Solomevich S.O., Bychkovsky P.M., Golub N.V., Alinovskaya V.A., Kosterova R.I., Kladiev A.A. Investigation of sorption interactions of an antineoplastic prospidin preparation with a gel-forming fast-swelling dextran phosphate // Proceedings BSU. Ser.  Physiological, Biochemical and Molecular Biology Sciences. 2013. Part. 1. Vol. 8. P. 27-36 (in rus).
  11. Yurkshtovich T.L., Solomevich S.O., Golub N.V., Alinovskaya V.A., Kosterova R.I., Bychkovskii P.M., Kladiev A.A.
  12. Sorption of the antitumor drug prospidinum on microgels of polysaccharide phosphates // Colloid. J. 2014. Vol. 76. № 5. С. 628-636.http://link.springer.com/article/10.1134/S1061933X14050172
  13. Yurkshtovich T.L., Solomevich S.O., Bychkovsky P.M., Golub N.V., Alinovskaya V.A., Kosterova R.I. The study of the mechanism of the synthesis of dextran gelling with phosphoric and carbamate groups // Proceedings BSU. Ser. Physiological, Biochemical and Molecular Biology Sciences. 2014. Part 2. Vol. 9. P. 164-172(in rus).
  14. ReutovichM.Yu., BychkovskyP.M., KraskoO.V., IstominYu.P., AleksandrovaE.N., ShmakA.I., YurkshtovichT.L., KaputskyF.N., GolubN.V., AlinovskayaV.A., KosterovaR.I., SolomevichS.O., RogovYu.I. Interperitonealchemotherapywithpolymer-immobilizedformofprospidinasciteshepadomaofZaidel// Vestn. BSU. Ser. 2. 2015. № 2. P. 29-37 (in rus).
  15. Solomevich S.O., Bychkovskii P.M., Yurkshtovich T.L., Golub N.V.  Influence of the properties of modified dextran hydrogel polymer network on the kinetics of the release of prospidin antitumor agent //  Rus. J. Appl. Chem.2016. Vol. 89. № 8. С. 1302-1308.
  16. Yurkshtovich T.L., Golub N.V., Yurkshtovich N.K., Bychkovskii P.M., Kosterova R.I., Alinovskaya V.A. Microgels of Starch Phosphates for the Controlled Release of  Biomacromolecules // Biotekhnologiya. 2016. Vol. 32. № 3. Р. 67-77 (in rus).
  17. Reutovich M. Yu., Istomin Yu.P., Kras'ko O.V., Tretschalina B.M., Bychkovsky P.M., Yurkshtovich T.L., Shmak  A.I., Golub N.V., Alinovskaya V.A., Kosterova  R.I., Solomevich S.O., Rogov Yu.I. Reutovich M. Yu. Antitumor activity of the hydrogel form of cisplatinum on ascites hepadoma Zaidel  // Rus. J. Biotherapy. 2016. Vol. 15. № 4. P. 97-101(in rus).
Patents:
  1. Pat.RB № 12147 dated 21. 04. 2009. Solution of eye drops for the prevention or treatment of corneal epitheliopathy. Yurkshtovich N.K., Marchenko  L.N., Fedulov  A.S., Yurkshtovich T.L., Petrov P.T., Trukhacheva T.V., Belyaev S.M., Golub N.V., Kosterova R .I., Alinovskaya V.A., Golub O.M., Kazyuchits O.A., Tyurin V.I.
  2. Pat.  RF  No. 2442586  dated  18.09. 2010.  Hydrogel antitumor preparation. Yurkshtovich T.L.,  Kladiev A.A.,  Golub N.V., Bychkovsky P.M., Alinovskaya V.A., Kosterova R.I., Belyaev S.A., Krasny S.A.,  Alexandrova E.N.
  3. Pat. RB № 13363 dated 08. 04. 2010. A veterinary preparation possessing antimicrobial and antiviral activity. Prokulevich V.A., Yurkshtovich T.L., Golub N.V., Alinovskaya V.A., Kaluzhsky V.E.
  4. Pat. RB 15481 dated  08. 04. 2010. The drug, which has antimicrobial and anti-herpetic effect. Loginova N.V., Polozov G.I., Yurkshtovich T.L., Golub N.V., Cherniavskaya A.A., Kovalchuk T.V., Kosterova R.I.
  5. Pat. RB № 15136 dated 11. 08. 2011.  Method for obtaining the hydrogel of dextran phosphate. Yurkshtovich T.L., Belyaev S.A., Yurkshtovich N.K., Bychkovsky P.M., Golub N.V., Alinovskaya V.A., Kosterova R.I.
  6. Pat. RF № 2468804 dated 14. 11. 2011. Gel-forming mixed phosphoric acid and carbamate esters of dextran, a method for their preparation. Yurkshtovich T.L., Golub N.V., Yurkshtovich N.K., Kosterova R.I., Alinovskaya V.A., Bychkovsky P.M., Belyaev S.A.
  7. Pat. RF№ 2455007 dated 10.07. 2012. Amethodforproducinggellingphosphatesofdextran. YurkshtovichT.L., BelyaevS.A., YurkshtovichN.K., BychkovskyP.M., GolubN.V., AlinovskayaV.A.,KosterovaR.I.
Просмотров: 255