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Pavel Bychkovsky

EN | RU

Leading Researcher
PhD (Chemistry)
Docent (Associate professor)

Department: Laboratory of polysaccharides chemistry
e-mail: bychkovsky@tut.by
Phone: +375 (17) 209-55-86

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  • h-index (Scopus) – 8
  • h-index (Web of Science) – 3
  • h-index (РИНЦ) – 9

Current research activity

  • structural and chemical modification of polysaccharides of microbial, plant and animal origin, study of esterification patterns, alkylation and oxidation of polysaccharides, study of the physicochemical and medico-biological properties of modified polysaccharides for the creation of medical materials;
  • study of the patterns of sorption interactions of modified polysaccharides with biomacromolecules and low molecular weight physiologically active substances to create systems for targeted delivery of chemotherapy drugs;
  • development of innovative drugs with prolonged action based on modified polysaccharides, development and implementation of technological processes for their production, development of modern validated methods for determining the qualitative and quantitative characteristics of drugs.

Awards

  1. Certificate of honor of the Council of Ministers of the Republic of Belarus (2020).
  2. Awarded with honorary title "Minsker of the Year" (2019);
  3. Ministry of Education badge (2019);
  4. Awarded with the "Excellence in Health Care of the Republic of Belarus" sign (2018);
  5. Certificate of honor of the RI PHP BSU (2018);
  6. Commendation from the Chairman of the Minsk City Executive Committee (2017);
  7. Awarded the Honorary title "Honored Worker of BSU"(2017);
  8. BSU rector commendation (2016);
  9. Diploma of the Ministry of Education of the Republic of Belarus (2016);
  10. Minsk City Executive Committee Certificate of honor (2016);
  11. Certificate of honor from the Department of Pharmaceutical Industry of the Ministry of Health of the Republic of Belarus (2016);
  12.  Certificate of honor of the National Academy of Sciences of the Republic of Belarus (2016);
  13. Certificate of honor of the Ministry of Education of the Republic of Belarus (2015);
  14. Certificate of honor of the State Committee on Science and Technology of Belarus (2015);
  15. Gratitude from the rector of BSU (2014);
  16. Diploma of the Ministry of Education of the Republic of Belarus (2011);
  17. Certificate of honor of the Ministry of Health of the Republic of Belarus (2011);
  18. BSU diploma (2010);
  19. Certificate of BSU (2008);
  20. Certificate of honor of BSU (2004);
  21. Diploma of the Ministry of Education of the Republic of Belarus (2002);
  22. Certificate of honor of the National Assembly of the Republic of Belarus (2001);

List of Selected Publications:

  1. Solomevich S.O., Aharodnikau U.E., Dmitruk E.I., Nikishau P.A., Bychkovsky P.M., Salamevich D.A., Jiang G., Pavlov K.I., Sun Y., Yurkshtovich T.L. Chitosan–dextran phosphate carbamate hydrogels for locally controlled co-delivery of doxorubicin and indomethacin: From computation study to in vivo pharmacokinetics // International Journal of Biological Macromolecules. 2023. 228: 273-285.
  2. Yurkshtovich T.L., Yurkshtovich N.K., Golub N.V., Kosterova R.I., Pristromova Y.I., Solomevich S.O., Bychkovsky P.M. Rheological properties and in vitro hydrolytic stability of the carboxymethylcellulose–dioxidine composition // Proceedings of the National Academy of Sciences of Belarus, Chemical Series. 2022. 58(1): 7-16.   DOI 10.29235/1561-8331-2022-58-1-7-16
  3. Solomevich S.O., Dmitruk E.I., Aharodnikau U.E., Salamevich D.A., Bychkovsky P.M., Golub N.V., Yurkshtovich T.L. Characterization of H3PO4/HNO3–NANO2 oxidized bacterial cellulose and its usage as a carrier for the controlled release of cephalexin // Cellulose. 2021; 28(14): 9425-39.
  4. Solomevich S.O., Dmitruk E.I., Bychkovsky P.M., Salamevich D.A., Kuchuk S.V., Yurkshtovich T.L. Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications // International Journal of Biological Macromolecules. 2021. 1;169:500-12.
  5. Gofman I.V., Nikolaeva A.L., Khripunov A.K., Ivan’kova E.M., Shabunin A.S., Yakimansky A.V., Romanov D.P., Popov  A.L., Ermakov A.M., Solomevich S.O., Bychkovsky P.M., Baranchikov A.E., Ivanov V.K.  Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation // Polymers. 2021, 13: 12: 1999.
  6. Solomevich SO, Cherkasova AV, Salamevich DA, Aharodnikau UE, Bychkovsky PM, Yurkshtovich TL. Millimeter-sized chitosan/dextran phosphate capsules and calcium/dextran phosphate beads for regulating prospidine release // Materials Letters. 2021 15;293:129720.
  7. Yunusov K.E., Sarymsakov A.A., Turakulov F.M., Rashidova S.S., Yurkshtovich T.L., Kokhan A.V., Yurkshtovich N.K., Alinovskaya V.A., Bychkovskii P.M., Golub N.V., Solomevich S.O. Synthesis of selenium nanoparticles stabilized with sodium carboxymethylcellulose for preparation of a long-acting form of prospidine // Russian Journal of Applied Chemistry. 2021; 94: 1259-66.
  8. Solomevich S.O., Dmitruk E.I., Bychkovsky P.M., Nebytov A.E., Yurkshtovich T.L., Golub N.V. Fabrication of oxidized bacterial cellulose by nitrogen dioxide in chloroform/cyclohexane as a highly loaded drug carrier for sustained release of cisplatin // Carbohydrate polymers. 2020: 15; 248: 116745.
  9. Solomevich S.O., Bychkovsky P.M., Yurkshtovich T.L., Golub N.V., Mirchuk P.Y., Revtovich M.Y., Shmak A.I. Biodegradable pH-sensitive prospidine-loaded dextran phosphate based hydrogels for local tumor therapy // Carbohydrate Polymers. 2019. Vol. 226. P. 115308-115314.
  10. Yurkshtovich T.L., Golub N.V., Solomevich S.O., Kosterova R.I., Yurkshtovich N.K., Alinovskaya V.A., Bychkovsky P.M. Acid-basic properties and biological activity of starch phosphate in the form of microgels // Colloid Journal. 2019. Vol. 81. № 3. P. 329–336.
  11. Yurkshtovich T.L., Golub N.V., Solomevich S.O., Yurkshtovich N.K., Bychkovsky P.M., Kosterova R.I., Alinovskaya V.A. Effect of the composition of an esterification mixture on the acid properties of gel-forming phosphorylated polysaccharides // Russian Journal of Physical Chemistry A. 2019. Vol. 93. № 9. P. 1817–1824.
  12. Bychkovsky P.M., Yurkshtovich T.L., Golub N.V., Solomevich S.O., Yurkshtovich N.K., Adamchik D.A. Biological films based on oxidized bacterial cellulose: obtaining, structure, properties // Polymer Science, Series B. 2019. 61(4). P. 433–441.
  13. Yurkshtovich T.L., Golub N.V., Yurkshtovich N.K., Bychkovsky P.M., Kosterova R.I., Alinovskaya V.A. The microgels of starch phosphates for the controlled release of biomacromolecules // Appl. Biochem. Microbiology. 2017. 53.8. Р. 78-86.
  14. Solomevich S.O., Bychkovskii P.M., Yurkshtovich T.L., Golub N.V. Influence of the properties of modified dextran hydrogel polymer network on the kinetics of the release of prospidin antitumor agent // Russian Journal of Applied Chemistry. 2016. Vol. 89. № 8. P. 1302−1308.
  15. Bychkouski P.M. Antitumor activity of Gel-forming preparation prospidin on the model of Zaidela ascetic hepatoma / P.M. Bychkouski, T.L. Yurkshtovich, A.A. Kladiev, and M. Yu. Revtovich // Cell and Tissue Biology. 2012. Vol. 6. № 3. P. 233-239.
  16. Sheleg S.V., Korotkevich E.A., Zhavrid E.A., Muravskaya G.V., Smeyanovich A.F., Shanko Y.G., Yurkshtovich T.L., Bychkovsky P.M., Belyaev S.A. Local chemotherapy with cisplatin-depot for glioblastoma multiforme // Journal of Neuro-oncology. 2002. Vol. 60. P. 53−59.
  17. Zimnitsky D.S., Yurkshtovich T.L., Bychkovsky P.M. Multilayer adsorption of amino acids on oxidized cellulose // J. Colloid and Interface Sci. 2005. Vol. 285. № 2. P. 502-508.
  18. Zimnitsky D.S., Yurkshtovich T.L., Bychkovsky P.M. Adsorption of zwitterionic drugs on oxidized cellulose from agueous solutions // Reactive & Functional Polumers. 2006. Vol. 66. P. 519-525.
  19. D.S. Zimnitsky, T.L. Yurkshtovich, P.M. Bychkovsky. Adsorption of zwitterionic drugs onto oxidized cellulose // J. Colloid and Interface Science. 2006. Vol. 295. P.33-40.
  20. D.S. Zimnitsky, T.L. Yurkshtovich, P.M. Bychkovsky. Synthesis and characterization of oxidized cellulose. Journal of Polymer Science. Part A: Polymer Chemistry. 2004. Vol. 42. № 19. P. 4785−4791.
  21. D.S. Zimnitsky, T.L. Yurkshtovich, P.M. Bychkovsky. Adsorption of zwitterionic drugs on oxidized cellulose from aqueous and water/alcohol solutions // J. Physical Chemistry B. 2004. Vol. 108. № 46. P. 17812−17817.

Patents

  1. United States Patent № US 10,806,732 B2 (20.10.2020). Stable anti-neoplastic pharmaceutical composition comprising temozolomide and method of preparing the composition;
  2. Indian patent № 352963  (3.12.2020). Stable anti-neoplastic pharmaceutical composition comprising temozolomide and method of preparing the composition;
  3. EUR №033140, (2019);
  4. EUR №031596 (2019);
  5. PCT/SE2017/050418 №1000102174  (2017).  «Stable anti-neoplastic pharmaceutical composition comprising temozolomide and method of preparing the composition».
  6. BY № 20953  (2014);
  7. BY № 20954  (2014);
  8. BY № 9616   (2013);
  9. BY № 15961  (2012);
  10. BY № 16085 (2012);
  11. BY № 16415 (2012);   
  12. BY № 2442586 (2012); 
  13. RU № 2455007 (2012); 
  14. RU №2468804  (2012); 
  15. BY № 14762 МПК7 А 61К33/24, 47/38 (2009);
  16. BY № 15136 (2009);
  17. BY №16349  (2012); 
  18. BY № 6803  (2004); 
  19. BY № 7258  (2005);  
  20. BY № 6420  (2004); 
  21. BY № 6157  (2003); 
  22. BY №2049  (1998); 
  23. BY № 2049   (1995).