НИИ ФХП БГУ

Research Institute for Physical Chemical Problems
of the Belarusian State University

Bioresoluted medicine “Cisplacel”

 

Противоопухолевое лекарственное
средство Цисплацел


phone: +375 (17) 328-62-29;209-55-86
e-mail: Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра.; Этот адрес электронной почты защищен от спам-ботов. У вас должен быть включен JavaScript для просмотра.

Patent BY № 6420

Assignment
The medicine “Cisplacel” provides local cytostatic antitumoral effect and intendent for implantation in ablated supratentorial neuroepithelial tumor bed of brain, in soft-tissues and cavities in the locality of insufficient radical removed tumour of head and neck organs. “Cisplacel” possesses by cytostatic and styptic actions and bioresorpted pending 20-30 days after   the implantation
 
Pharmacological action:
Conditioned by cytostatic effect of immobilized on the oxidized cellulose base (pharmacological group of alkylating agents). The mechanism of action is stipulated by the activity of inhibition of biosynthesis of DNA, blocking of DNA by means of production interstrand cross-links in DNA, what leads to destruction of cells in all levels of cell cycle.
 
 Indication for usage
  • malignant tumor brain;
  • malignant tumor of the neck, oral cavity, tongue, nose, accessory sinuses of nose;
  • adult soft tissue sarcoma.

Pharmacological action:
Conditioned by cytostatic effect of immobilized on the oxidized cellulose base (pharmacological group of alkylating agents). The mechanism of action is stipulated by the activity of inhibition of biosynthesis of DNA, blocking of DNA by means of production interstrand cross-links in DNA, what leads to destruction of cells in all levels of cell cycle.

Implantation of the medicine “Cisplacel” in the tumor bed of the removed supratentorial glioma brain
 
 


Description of the medicine
-     knitted fabric tissue of white-yellow or yellow tone colour without odour (can be moderately dissolved in 1M of hydroxide sodium solution);
-     the size of the tissues 1,5 х1,5 cm or 3,0 х5,0 сm
-     tightness of cytostatic 1±0,15 mg/cm2
 
Advantages
-      purposeful transportation of cytostatic agent in the affected organ’s area, prolongation of medical effect;
-      reduction of cytostatic agent dosage and reduction of toxic body burden;
-      achievement of hemostasis;
-      complete bioresorption during implantation.
 
Expert opinion
Doctor of Medical Sciences Yuri Shanko, the Head of the Neurology and Neurosurgery Chair at the Belarusian Medical Academy of Post-Graduate Education: “I’ve tested ‘Cisplacel’ clinically — while operating on cerebral tumours. It’s sometimes extremely difficult to reach a tumour in the cranial cavity and side effects can include loss of vision, hearing, movement and other functions. In these cases, ‘Cisplacel’ is a good assistant. The medicine — in the form of small napkins — is placed on the walls of the brain. The napkins are made of oxygen­ised cellulose which completely dissolves in 1-1.5 months. During this time, the medicine is released gradually in small doses — killing dissipated tumour cells to a depth of one centimetre. As a result, relapses are rarer. ‘Cisplacel’ prolongs life by about 30-50 percent in comparison to previous cases”
Просмотров: 1721